Huperzia serrata

From Wikipedia, the free encyclopedia
Huperzia serrata
Lycopodium serratum tougesiba01.jpg
Conservation status

Secure (NatureServe)
Scientific classification
Kingdom: Plantae
Division: Lycopodiophyta
Class: Lycopodiopsida
Order: Lycopodiales
Family: Huperziaceae
Genus: Huperzia
Species: H. serrata
Binomial name
Huperzia serrata
(Thunb. ex Murray) Trevis.

Huperzia serrata (TCM = Qian Ceng Ta/Jin Bu Huan) is a plant known as a firmoss which contains the acetylcholinesteraseinhibitor huperzine A.[1] It is widely distributed over-the-counter as a nootropic and dietary supplement.[citation needed]

This species is native to India and southeast Asia.

Catharanthus roseus

From Wikipedia, the free encyclopedia
Madagascar rosy periwinkle
Catharanthus roseus24 08 2012 (1).JPG
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
(unranked): Asterids
Order: Gentianales
Family: Apocynaceae
Genus: Catharanthus
Species: C. roseus
Binomial name
Catharanthus roseus
(L.) G.Don
  • Vinca rosea (basionym)
  • Ammocallis rosea
  • Lochnera rosea

Catharanthus roseus, commonly known as the Madagascar rosy periwinkle, is a species of Catharanthus native andendemic to Madagascar. Other English names occasionally used include Cape periwinkle, rose periwinkle, rosy periwinkle, and “old-maid”.[1][2]


Two varieties are recognized

  • Catharanthus roseus var. roseus
Synonymy for this variety

Catharanthus roseus var. angustus Steenis ex Bakhuizen f.[3]
Catharanthus roseus var. albus G.Don [4]
Catharanthus roseus var. occellatus G.Don[5]
Catharanthus roseus var. nanusMarkgr.[6]
Lochnera rosea f. alba (G.Don) Woodson[7]
Lochnera rosea var. ocellata (G.Don) Woodson
  • Catharanthus roseus var. angustus (Steenis) Bakh. f.[8]
Synonymy for this variety

Catharanthus roseus var. nanus Markgr.[9]
Lochnera rosea var. angusta Steenis [10]


It is an evergreen subshrub or herbaceous plant growing 1 m tall. The leaves are oval to oblong, 2.5–9 cm long and 1–3.5 cm broad, glossy green, hairless, with a pale midrib and a short petiole 1–1.8 cm long; they are arranged in opposite pairs. The flowers are white to dark pink with a darker red centre, with a basal tube 2.5–3 cm long and a corolla 2–5 cm diameter with five petal-like lobes. The fruit is a pair of follicles 2–4 cm long and 3 mm broad.[11][12][13][14]

In the wild, it is an endangered plant; the main cause of decline is habitat destruction by slash and burn agriculture.[15] It is also however widely cultivated and isnaturalised in subtropical and tropical areas of the world.[11]

Pale Pink with Red Centre Cultivar

Cultivation and uses[edit]

The species has long been cultivated for herbal medicine and as an ornamental plant. In Ayurveda (Indian traditional medicine) the extracts of its roots and shoots, though poisonous, is used against several diseases.[citation needed] Intraditional Chinese medicine, extracts from it have been used against numerous diseases, including diabetes, malaria, and Hodgkin’s lymphoma.[12] The substances vinblastine and vincristine extracted from the plant are used in the treatment of leukemia [15] and Hodgkin’s lymphoma.

This conflict between historical indigenous use, and recent patents on C.roseus-derived drugs by western pharmaceuticalcompanies, without compensation, has led to accusations of biopiracy.[16]

It can be dangerous if consumed orally.[15] It can be extremely toxic, and is cited (under its synonym Vinca rosea) inLouisiana State Act 159.

As an ornamental plant, it is appreciated for its hardiness in dry and nutritionally deficient conditions, popular in subtropical gardens where temperatures never fall below 5 °C to 7 °C, and as a warm-season bedding plant in temperate gardens. It is noted for its long flowering period, throughout the year in tropical conditions, and from spring to late autumn, in warm temperate climates. Full sun and well-drained soil are preferred. Numerous cultivars have been selected, for variation in flower colour (white, mauve, peach, scarlet and reddish-orange), and also for tolerance of cooler growing conditions in temperate regions. Notable cultivars include ‘Albus’ (white flowers), ‘Grape Cooler’ (rose-pink; cool-tolerant), the Ocellatus Group (various colours), and ‘Peppermint Cooler’ (white with a red centre; cool-tolerant).[11]

C. roseus is used in plant pathology as an experimental host for phytoplasmas.[17] This is because it is easy to infect with a large majority of phytoplasmas, and also often has very distinctive symptoms such as phyllody and significantly reduced leaf size.[18]


Rosinidin is an anthocyanidin pigment found in the flowers of C. roseus.[19]

Other names[edit]

C. roseus is known as “Noyon Tora”(Assamese:নয়নতৰা)in Assamese,”noyontara” (Bengali: নয়নতারা) in Bengali, sadaphuli (Marathi: सदाफुली) in Marathi, boa-noite(“good night”) and maria-sem-vergonha (“shameless maria”, name shared with Impatiens and Thunbergia alata) in Portuguese (American), vinca-de-madagáscar,vinca-de-gato (“cats’ vinca”), vinca-branca (white vinca), vinca or boa-noite in Portuguese (European), vinca del Cabo, vinca rosa (“pink vinca”) or vinca rosada(“roseous vinca”) in Spanish, putica (“little whore”) in Venezuela and nityhakalyani in Tamil (Tamil: நித்யகல்யாணி பூ).

Ginkgo biloba

From Wikipedia, the free encyclopedia
This article is about the tree. For the Goethe poem, see Gingo biloba.
Ginkgo biloba
Temporal range: 49.5–0Ma


Mature tree
Conservation status
Scientific classificatione
Kingdom: Plantae
Division: Ginkgophyta
Class: Ginkgoopsida
Order: Ginkgoales
Family: Ginkgoaceae
Genus: Ginkgo
Species: G. biloba
Binomial name
Ginkgo biloba

Ginkgo (Ginkgo biloba; in Chinese, Korean and Japanese: 銀杏, pinyin romanization: yín xìng, Revised romanization: “eun haeng”, Hepburn romanization: ichō or ginnan, Vietnamese: bạch quả), often misspelled gingko[3] and also known as themaidenhair tree, is a unique species of tree with no living relatives. The ginkgo is a living fossil, recognisably similar to fossils dating back 270 million years. Native to China,[4] the tree is widely cultivated and was introduced early to human history. It has various uses in traditional medicine and as a source of food.

Ginkgo biloba cross section of tree trunk (source: MHNT)


Ginkgos are large trees, normally reaching a height of 20–35 m (66–115 feet), with some specimens in China being over 50 m (164 feet). The tree has an angular crown and long, somewhat erratic branches, and is usually deep rooted and resistant to wind and snow damage. Young trees are often tall and slender, and sparsely branched; the crown becomes broader as the tree ages. During autumn, the leaves turn a bright yellow, then fall, sometimes within a short space of time (one to 15 days). A combination of resistance to disease, insect-resistant wood and the ability to form aerial roots and sprouts makes ginkgos long-lived, with some specimens claimed to be more than 2,500 years old.

Ginkgo is a relatively shade-intolerant species that (at least in cultivation) grows best in environments that are well-watered and well-drained. The species shows a preference for disturbed sites; in the “semiwild” stands at Tian Mu Shan, many specimens are found along stream banks, rocky slopes, and cliff edges. Accordingly, ginkgo retains a prodigious capacity for vegetative growth. It is capable of sprouting from embedded buds near the base of the trunk (lignotubers, or basal chi chi) in response to disturbances, such as soil erosion. Old individuals are also capable of producing aerial roots on the undersides of large branches in response to disturbances such as crown damage; these roots can lead to successful clonal reproduction upon contacting the soil. These strategies are evidently important in the persistence of ginkgo; in a survey of the “semiwild” stands remaining in Tianmushan, 40% of the specimens surveyed were multistemmed, and few saplings were present.[5]


Ginkgo branches grow in length by growth of shoots with regularly spaced leaves, as seen on most trees. From the axils of these leaves, “spur shoots” (also known as short shoots) develop on second-year growth. Short shoots have very shortinternodes (so they may grow only one or two centimeters in several years) and their leaves are usually unlobed. They are short and knobby, and are arranged regularly on the branches except on first-year growth. Because of the short internodes, leaves appear to be clustered at the tips of short shoots, and reproductive structures are formed only on them (see pictures below – seeds and leaves are visible on short shoots). In ginkgos, as in other plants that possess them, short shoots allow the formation of new leaves in the older parts of the crown. After a number of years, a short shoot may change into a long (ordinary) shoot, or vice versa.[citation needed]


Ginkgo leaves in summer

Ginkgo leaves in autumn

The leaves are unique among seed plants, being fan-shaped with veins radiating out into the leaf blade, sometimes bifurcating (splitting), but never anastomosing to form a network.[6] Two veins enter the leaf blade at the base and fork repeatedly in two; this is known as dichotomous venation. The leaves are usually 5–10 cm (2–4 in), but sometimes up to 15 cm (6 in) long. The old popular name “maidenhair tree” is because the leaves resemble some of the pinnae of the maidenhair fern, Adiantum capillus-veneris. Ginkgos are prized for their autumn foliage, which is a deep saffron yellow.

Leaves of long shoots are usually notched or lobed, but only from the outer surface, between the veins. They are borne both on the more rapidly growing branch tips, where they are alternate and spaced out, and also on the short, stubby spur shoots, where they are clustered at the tips.


Ginkgos are dioecious, with separate sexes, some trees being female and others being male. Male plants produce smallpollen cones with sporophylls, each bearing two microsporangia spirally arranged around a central axis.

Female plants do not produce cones. Two ovules are formed at the end of a stalk, and after pollination, one or both develop into seeds. The seed is 1.5–2 cm long. Its fleshy outer layer (the sarcotesta) is light yellow-brown, soft, and fruit-like. It is attractive in appearance, but contains butyric acid[7] (also known as butanoic acid) and smells like rancid butter or vomit[8]when fallen. Beneath the sarcotesta is the hard sclerotesta (the “shell” of the seed) and a papery endotesta, with thenucellus surrounding the female gametophyte at the center.[9]

Pollen cones

The fertilization of ginkgo seeds occurs via motile sperm, as in cycads, ferns, mosses and algae. The sperm are large (about 70–90 micrometres)[10] and are similar to the sperm of cycads, which are slightly larger. Ginkgo sperm were first discovered by the Japanese botanist Sakugoro Hirase in 1896.[11] The sperm have a complex multi-layered structure, which is a continuous belt of basal bodies that form the base of several thousand flagella which actually have a cilia-like motion. The flagella/cilia apparatus pulls the body of the sperm forwards. The sperm have only a tiny distance to travel to the archegonia, of which there are usually two or three. Two sperm are produced, one of which successfully fertilizes the ovule. Although it is widely held that fertilization of ginkgo seeds occurs just before or after they fall in early autumn,[6][9] embryos ordinarily occur in seeds just before and after they drop from the tree.[12]

Distribution and habitat[edit]

Although Ginkgo biloba and other species of the genus were once widespread throughout the world, its range shrank until by two million years ago, it was restricted to a small area of China. For centuries, it was thought to be extinct in the wild, but is now known to grow in at least two small areas in Zhejiang province in eastern China, in the Tianmushan Reserve. However, recent studies indicate high genetic uniformity among ginkgo trees from these areas, arguing against a natural origin of these populations and suggesting the ginkgo trees in these areas may have been planted and preserved by Chinese monks over a period of about 1,000 years.[13]This study demonstrates a greater genetic diversity in Southwestern China populations, supporting glacial refugia in mountains surrounding eastern Qinghai-Tibet Plateau, where several old-grow, candidates to wild populations have been reported.[13][14] Whether native ginkgo populations still exist has not been demonstrated unequivocally, but evidence grows favouring these Southwestern populations as wild, from genetic data but also from history of those territories, with bigger Ginkgo biloba trees being older than surrounding human settlements.[13]

Where it occurs in the wild, it is found infrequently in deciduous forests and valleys on acidic loess (i.e. fine, silty soil) with good drainage. The soil it inhabits is typically in the pH range of 5.0 to 5.5.[15]

In many areas of China, it has been long cultivated, and it is common in the southern third of the country.[15] It has also been commonly cultivated in North America for over 200 years and in Europe for close to 300, but during that time, it has never become significantly naturalized.[16]

Taxonomy and naming[edit]

The species was initially described by Linnaeus in 1771, the specific epithet biloba derived from the Latin bis, ‘two’ and loba, ‘lobed’, referring to the shape of the leaves.[17] Two names for the species recognise the botanist Richard Salisbury, a placement by Nelson as Pterophyllus salisburiensis and the earlier Salisburia adiantifolia proposed by James Edward Smith. The epithet of the latter may have been intended to denote a characteristic resembling Adiantum, the genus of maidenhair ferns.[18]

The relationship of ginkgo to other plant groups remains uncertain. It has been placed loosely in the divisions Spermatophyta and Pinophyta, but no consensus has been reached. Since its seeds are not protected by an ovary wall, it can morphologically be considered a gymnosperm. The apricot-like structures produced by female ginkgo trees are technically not fruits, but are seeds that have a shell consisting of a soft and fleshy section (the sarcotesta), and a hard section (thesclerotesta).

The ginkgo is classified in its own division, the Ginkgophyta, comprising the single class Ginkgoopsida, order Ginkgoales, family Ginkgoaceae, genus Ginkgo and is the only extant species within this group. It is one of the best-known examples of a living fossil, because Ginkgoales other than G. biloba are not known from the fossil record after the Pliocene.[19][20]


The older Chinese name for this plant is 銀果, meaning “silver fruit”, pronounced yínguǒ in Mandarin or Ngan-gwo in Cantonese. The most usual names today are 白果 (bái guǒ), meaning “white fruit”, and 銀杏 (yínxìng), meaning “silver apricot“. The former name was borrowed directly in Vietnamese as bạch quả. The latter name was borrowed in Japanese ぎんなん (ginnan) and Korean 은행 (eunhaeng), when the tree itself was introduced from China.

The scientific name Ginkgo is the result of a spelling error that occurred three centuries ago. Kanji typically have multiple pronunciations in Japanese, and the characters 銀杏 used for ginnan can also be pronounced ginkyō. Engelbert Kaempfer, the first Westerner to investigate the species in 1690, wrote down this pronunciation in his notes he later used for the Amoenitates Exoticae (1712) with the “awkward” spelling “ginkgo”. This appears to be a simple error of Kaempfer, taking his spelling of other Japanese words containing the syllable “kyō” into account, a more precise romanization following his writing habits would have been “ginkio” or “ginkjo”.[21] Linné, who relied on Kaempfer when dealing with Japanese plants adopted the spelling given in Kaempfer’s “Flora Japanica” (Amoenitates Exoticae, p. 811).


Ginkgo biloba Eocene leaf from the McAbee, BC, Canada.

Fossil Ginkgo leaves from the Jurassic of England

The ginkgo is a living fossil, with fossils recognisably related to modern ginkgo from the Permian, dating back 270 million years. The most plausible ancestral group for the order Ginkgoales is the Pteridospermatophyta, also known as the “seed ferns”, specifically the order Peltaspermales. The closest living relatives of the clade are the cycads,[22] which share with the extant G. biloba the characteristic of motile sperm. Fossils attributable to the genus Ginkgo first appeared in the Early Jurassic, and the genus diversified and spread throughout Laurasia during the middle Jurassic and Early Cretaceous. It declined in diversity as the Cretaceous progressed, and by the Paleocene, Ginkgo adiantoides was the only Ginkgo species left in the Northern Hemisphere, while a markedly different (and poorly documented) form persisted in the Southern Hemisphere. At the end of the Pliocene, Ginkgo fossils disappeared from the fossil record everywhere except in a small area of central China, where the modern species survived. It is doubtful whether the Northern Hemisphere fossil species of Ginkgocan be reliably distinguished. Given the slow pace of evolution and morphological similarity between members of the genus, there may have been only one or two species existing in the Northern Hemisphere through the entirety of the Cenozoic: present-day G. biloba (including G. adiantoides) and G. gardneri from the Paleocene of Scotland.[23]

At least morphologically, G. gardneri and the Southern Hemisphere species are the only known post-Jurassic taxa that can be unequivocally recognised. The remainder may have been ecotypes or subspecies. The implications would be that G. biloba had occurred over an extremely wide range, had remarkable genetic flexibility and, though evolving genetically, never showed much speciation. While it may seem improbable that a species may exist as a contiguous entity for many millions of years, many of the ginkgo’s life-history parameters fit. These are: extreme longevity; slow reproduction rate; (in Cenozoic and later times) a wide, apparently contiguous, but steadily contracting distribution coupled with, as far as can be demonstrated from the fossil record, extreme ecological conservatism (restriction to disturbed streamside environments).[24]

Modern-day G. biloba grows best in environments that are well-watered and drained,[25] and the extremely similar fossilGinkgo favored similar environments: the sediment record at the majority of fossil Ginkgo localities indicates it grew primarily in disturbed environments along streams and levees.[24] Ginkgo, therefore, presents an “ecological paradox” because while it possesses some favorable traits for living in disturbed environments (clonal reproduction) many of its other life-history traits (slow growth, large seed size, late reproductive maturity) are the opposite of those exhibited by modern plants that thrive in disturbed settings.[26]

Given the slow rate of evolution of the genus, Ginkgo possibly represents a preangiosperm strategy for survival in disturbed streamside environments. Ginkgo evolved in an era before flowering plants, when ferns, cycads, and cycadeoids dominated disturbed streamside environments, forming low, open, shrubby canopies.Ginkgo’s large seeds and habit of “bolting” – growing to a height of 10 m before elongating its side branches – may be adaptions to such an environment. Because diversity in the genus Ginkgo drops through the Cretaceous (along with that of ferns, cycads, and cycadeoids) at the same time the flowering plants were on the rise, the notion that flowering plants with better adaptations to disturbance displaced Ginkgo and its associates over time is supported.[27]

Ginkgo has been used for classifying plants with leaves that have more than four veins per segment, while Baiera for those with fewer than four veins per segment.Sphenobaiera has been used to classify plants with a broadly wedge-shaped leaf that lacks a distinct leaf stem. Trichopitys is distinguished by having multiple-forked leaves with cylindrical (not flattened), thread-like ultimate divisions; it is one of the earliest fossils ascribed to the Ginkgophyta.[citation needed]

A digital recreation of Baiera made from diverse images of fossils and academic descriptions

Cultivation and uses[edit]

Symbol of Tokyo prefecture, representing a ginkgo leaf.

Ginkgo has long been cultivated in China; some planted trees at temples are believed to be over 1,500 years old. The first record of Europeans encountering it is in 1690 in Japanese temple gardens, where the tree was seen by the German botanist Engelbert Kaempfer. Because of its status in Buddhism and Confucianism, the ginkgo is also widely planted in Korea and parts of Japan; in both areas, some naturalization has occurred, with ginkgos seeding into natural forests.

In some areas, most intentionally planted ginkgos are male cultivars grafted onto plants propagated from seed, because the male trees will not produce the malodorous seeds. The popular cultivar “Autumn Gold” is a clone of a male plant.

The disadvantage of male ginkgo biloba trees is that they are highly allergenic. Male ginkgo biloba trees have an OPALS allergy scale rating of 7 (out of 10), while female trees, which can produce no pollen, have an OPALS allergy scale rating of 2.[29]

Female cultivars include “Liberty Splendor”, “Santa Cruz”, and “Golden Girl”, so named because of the striking yellow color of its leaves in the fall.

Ginkgos adapt well to the urban environment, tolerating pollution and confined soil spaces.[30] They rarely suffer disease problems, even in urban conditions, and are attacked by few insects.[31][32] For this reason, and for their general beauty, ginkgos are excellent urban and shade trees, and are widely planted along many streets.

Ginkgos are also popular subjects for growing as penjing and bonsai;[33] they can be kept artificially small and tended over centuries. Furthermore, the trees are easy to propagate from seed.

The ginkgo leaf is the symbol of the Urasenke school of Japanese tea ceremony. The tree is the national tree of China, and is the official tree of the Japanese capital of Tokyo, and the symbol of Tokyo is a ginkgo leaf.


Extreme examples of the ginkgo’s tenacity may be seen in Hiroshima, Japan, where six trees growing between 1–2 km from the 1945 atom bomb explosion were among the few living things in the area to survive the blast.[34] While almost all other plants (and animals) in the area were destroyed, the ginkgos, though charred, survived and were soon healthy again. The trees are alive to this day.

Culinary use[edit]

Ginkgo seeds with sarcotesta removed

Ginkgo seeds served with boiled coconut flesh as a dessert in Thailand

The nut-like gametophytes inside the seeds are particularly esteemed in Asia, and are a traditional Chinese food. Ginkgo nuts are used in congee, and are often served at special occasions such as weddings and the Chinese New Year (as part of the vegetarian dish called Buddha’s delight). In Chinese culture, they are believed to have health benefits; some also consider them to have aphrodisiac qualities. Japanese cooks add ginkgo seeds (called ginnan) to dishes such as chawanmushi, and cooked seeds are often eaten along with other dishes.

When eaten in large quantities or over a long period, especially by children[35] the gametophyte (meat) of the seed can cause poisoning by 4′-O-methylpyridoxine (MPN). MPN is heat stable and not destroyed by cooking.[35] Studies have demonstrated the convulsions caused by MPN can be prevented or terminated with pyridoxine.

Some people are sensitive to the chemicals in the sarcotesta, the outer fleshy coating. These people should handle the seeds with care when preparing the seeds for consumption, wearing disposable gloves. The symptoms are allergic contact dermatitis[36][37] or blisters similar to that caused by contact with poison ivy. However, seeds with the fleshy coating removed are mostly[clarification needed][quantify] safe to handle.

Ginkgo biloba in Tournai,Belgium

Potential medicinal uses[edit]

Extracts of ginkgo leaves contain flavonoid glycosides (myricetin and quercetin)[38] and terpenoids (ginkgolides, bilobalides) and have been used pharmaceutically. These extracts are shown to exhibit reversible, nonselective monoamine oxidase inhibition, as well as inhibition of reuptake at the serotonin, dopamine, and norepinephrine transporters, with all but the norepinephrine reuptake inhibition fading in chronic exposure.[39] Ginkgo extract has in addition been found to act as a selective 5-HT1A receptor agonist in vivo.[40] Ginkgo supplements are usually taken in the range of 40–200 mg per day. In 2010, a meta-analysis of clinical trials has shown Ginkgo to be moderately effective in improving cognition in dementia patients[41] but not preventing the onset of Alzheimer’s disease in people without dementia.[42][43] In research not yet confirmed by clinical or governmental agencies, ginkgo may have some efficacy in treating the symptoms of schizophrenia.[44][45][46][47][48][49][50]

As a memory and concentration enhancement[edit]

Ginkgo is believed to have nootropic properties, and is mainly used as memory and concentration enhancer, and antivertigoagent.[51] However, studies differ about its efficacy. The largest and longest independent clinical trial to assess Ginkgo bilobapublished the finding in 2008 that the supplement does not reduce incidence of all-cause dementia or Alzheimer’s disease in adults 75 years or older who had normal cognition or mild cognitive impairment when given a twice-daily dose of 120 mg extract of G. biloba.[52][53] However, a similar trial published in December 2010 concluded the same extract formulation of G. biloba (EGb 761), when given as a single 240-mg daily dose, “was found significantly superior to placebo in the treatment of patients with dementia with neuropsychiatric symptoms” in a trial with 410 out-patients.[54]

According to some studies, Ginkgo can significantly improve attention in healthy individuals.[55][56] In one such study, the effect was almost immediate and reaches its peak 2.5 hours after the intake.[57]

One study suggests ginkgo’s purported effect on cognition may be attributable to its inhibitory effect on norepinephrine reuptake.[39]

Nonetheless, a meta-analysis in 2012[58] reported zero effect sizes for the impact of Ginkgo biloba on memory, attention and problem-solving in healthy individuals.

In dementia[edit]

Ginkgo has been studied as a possible treatment for Alzheimer’s disease. Preliminary studies were encouraging, but the current understanding is that Ginkgo is not an effective treatment or preventative for Alzheimer’s.[41][59] Research began with positive preclinical results in mice,[60] and a 2006 study found 160 mg of ginkgo extract to be as effective as a daily 5-mg dose of the cholinesterase inhibitor donepezil in human subjects.[61] A 2008 randomized controlled clinical trial found ginkgo ineffective at treating dementia in humans at a daily dose of 120 mg.[62][63] A similar trial published in 2010, however, found ginkgo effective at treating mild to moderate dementia at the higher single dose of 240 mg daily.[54] Another randomized controlled trial, published in 2009, found no benefit from ginkgo in preventing cognitive decline or dementia when given at a dose of 120 mg twice daily.[43] A similar study reported in 2012 concluded the long-term use of Ginkgo biloba extract does not affect progression to Alzheimer’s disease.[64] A recent meta-analysis of 9 studies of ginkgo for use in the treatment of dementia concluded it was more effective than placebo, although, like other dementia drugs, the clinical significance of these moderate effects was difficult to quantify.[41] An editorial in The Lancetconcluded ginkgo biloba does not prevent dementia in elderly individuals with or without memory complaints or cognitive impairment and is not effective for prevention of Alzheimer’s disease.[59]

In other symptoms[edit]

Of the many conflicting results from basic research, ginkgo extract may have three effects on the human body: improvement in blood flow to most tissues and organs, protection against oxidative cell damage from free radicals, and blockage of many of the effects of platelet-activating factor (platelet aggregation, blood clotting)[65]that have been related to the development of a number of cardiovascular, renal, respiratory and central nervous system disorders. Ginkgolides, especially ginkgolide B, are potent antagonists against platelet-activating factor, and thus may be useful in protection and prevention of thrombus, endotoxic shock, and from myocardial ischemia.[66]

Ginkgo has been studied as a potential treatment for sexual dysfunction related to SSRI use, but failed to show any effectiveness in placebo-controlled trials.[67][68]

The World Health Organization[69] reported possible medicinal uses of Ginkgo biloba shown in preliminary clinical research include treatment of the effects of mild to moderate cerebrovascular insufficiency[70] and of peripheral arterial occlusive diseases.[71] Cerebrovascular insufficiency, i.e. insufficient blood flow to the brain, may manifest itself as memory deficit, disturbed concentration or headaches. Other preliminary studies failed to show any effect of ginkgo on cognitive function in patients with multiple sclerosis.[72]

Side effects[edit]

Ginkgo biloba in Morlanwelz-Mariemont Park, Belgium

Ginkgo may have undesirable effects, especially for individuals with blood circulation disorders and those takinganticoagulants such as aspirin or warfarin, although recent studies have found ginkgo has little or no effect on the anticoagulant properties or pharmacodynamics of warfarin in healthy subjects.[73] Ginkgo inhibits monoamine oxidase,[74] so people who are taking certain types of antidepressants (such as monoamine oxidase inhibitors and selective serotonin reuptake inhibitors), as well as pregnant women, may experience side effects.[75][76]

Additional side effects include increased risk of bleeding, gastrointestinal discomfort, nausea, vomiting, diarrhea, headaches, dizziness, heart palpitations, and restlessness.[76][77]

Ginkgo biloba preparations have shown some carcinogenic effects in animal models, but they are not classified as human carcinogens.[78][79][80] The lowest observed dosages that caused adverse effect in these animal studies were at 100 mg/kg, and thus dosages that are impossible to reach by the consumption of Ginkgo Biloba preparations. Aside from possible complications in combination with anti-coagulant drugs, standardized preparations of Ginkgo biloba are safe, and side effects are rare.

Allergic precautions and contraindications to use[edit]

Some authors claim that Ginkgo biloba extracts, which are co-administered with anticoagulant drugs such as warfarin or coumadin, increase the risk for bleeding due to their assumed antiplatelet activity. Concerns that standardized Ginkgo biloba preparations (GBE) significantly impact haemostasis or adversely affect the safety of anticoagulant drugs are however not supported by current medical literature.[81]

The presence of amentoflavone in G. biloba leaves would indicate a potential for interactions with many medications through the strong inhibition of CYP3A4 andCYP2C9; however, no empirical evidence supports this. Further, at recommended doses, studies have shown, “[m]ultiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers.”[82] The concentration of amentoflavone found even in commercial ginkgo extracts possibly is too low to be pharmacologically active.

Ginkgo biloba leaves and sarcotesta also contain ginkgolic acids,[83] which are highly allergenic, long-chain alkylphenols such as bilobol or adipostatin A[84] (bilobol is a substance related to anacardic acid from cashew nut shells and urushiols present in poison ivy and other Toxicodendron spp.)[37] Individuals with a history of strong allergic reactions to poison ivy, mangoes, cashews and other alkylphenol-producing plants are more likely to experience allergic reaction when consuming non-standardized ginkgo-containing preparations, combinations, or extracts thereof. The level of these allergens in standardized pharmaceutical preparations fromGinkgo biloba was restricted to 5 ppm by the Commission E of the former Federal German Health Authority.

Review of chemicals in G. biloba[edit]

The plant also contains biflavones[85] Important constituents present in the medicinally used leaves are the terpene trilactones, i.e., ginkgolides A, B, C, J andbilobalide, many flavonol glycosides, biflavones, proanthocyanidins, alkylphenols, simple phenolic acids, 6-hydroxykynurenic acid, 4-O-methylpyridoxine andpolyprenols.[86]


From Wikipedia, the free encyclopedia
This article is about the plant genus. For the species in this genus that is widely used in herbal medicine, see Bacopa monnieri.
Starr 070815-8055 Bacopa monnieri.jpg
Bacopa monnieri
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
(unranked): Asterids
Order: Lamiales
Family: Plantaginaceae
Tribe: Gratioleae
Genus: Bacopa
See text.
Brami Adans.
Bramia Lam.
Herpestis Gaertn.
Macuillamia Raf.
Moniera P.Browne
Monocardia Pennell

Bacopa is a genus of 70 – 100 aquatic plants belonging to the family Plantaginaceae. It is commonly known as Waterhyssop(or Water Hyssop, though this is more misleading as Bacopa is not very closely related to hyssop but simply has a somewhat similar appearance).


They are annual or perennial, decumbent or erect stemmed plants. The leaves are opposite or whorled, sessile. Leaf blade regular, round to linear, venation palmate or pinnate. Stems hairy or smooth. The flowers are produced solitary or in pairs from leaf axil, usually radially symmetrical, sepals 5, petals 5, usually white, blue or purple in color. Dispersal and propagation is by seeds and stem fragments. Crushed leaves have a distinctive ‘lemon’ scent.

Bacopa myriophylloides

Habitat and range[edit]

Bacopa species are found in tropical and subtropical regions of the world, particularly theAmericas. A few are regarded as weeds and excess stock should not be dumped in warmer regions. Most grow in moist amphibious conditions, though some like B. myriophylloidesseem to be wholly aquatic.


Bacopa monnieri syn. Herpestis monniera, is important in Ayurvedic medicine and has been used, particularly in India, for several thousand years to improve mental functioning, including comprehension (Dhi), memory (Dhriti), and recollection (Smriti).[2]


Some of these species are commonly used in freshwater aquariums and around and in ponds in warmer climates. Most are easy to grow and are slow-growing, but require medium to high amounts of light. Most are easy to grow and will tolerate a wide range of water conditions. B. caroliniana at least will tolerate brackish water. Plants are usually best planted in groups in the middle to background. Algal infestation can be a problem in brighter lighting condition.[3]