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This article is outdated. Please update this article to reflect recent events or newly available information. (June 2015) |
Since 2012, an outbreak of Middle East respiratory syndrome coronavirus has affected several countries, primarily in its namesake, the Middle East. The virus, which causes Middle East respiratory syndrome (MERS), is a newly emergedbetacoronavirus that was first identified in a patient from Saudi Arabia in April 2012.
Sporadic cases, small clusters, and large outbreaks have been reported in 24 countries, with over 1000 cases of the virus and over 400 deaths.
Coronavirus
Most infections with human coronaviruses are mild and associated with common colds. The six coronaviruses known to infect humans are in the alpha and beta genera. Both MERS-CoV and SARS-CoV (severe acute respiratory syndrome) are betacoronaviruses.[12][13]
Global surveillance of potential epidemics and preparation has improved since and because of the SARS epidemic, and MERS is being closely monitored.[14][notes 1]
The Fourth Meeting of the International Health Regulations Emergency Committee concerning MERS-CoV was held on 4 December 2013. The committee decided that the conditions for a Public Health Emergency of International Concern (PHEIC) had not at present been met.[15]
Epidemiology[edit]
MERS-CoV cases worldwide:
100+ confirmed cases
50+ confirmed cases
1+ confirmed cases
In November 2012, Egyptian virologist Dr. Ali Mohamed Zaki sent a virus sample from the first confirmed case to virologist Ron Fouchier, a leading coronavirus researcher at theErasmus Medical Center (EMC) in Rotterdam, The Netherlands.[16] The second laboratory-proven case was in London, confirmed by the UK Health Protection Agency(HPA).[17][18] The HPA named the virus the London1_novel CoV 2012.[19]
On 8 November 2012, in an article published in the New England Journal of Medicine, Dr. Zaki and co-authors from the Erasmus Medical Center published more details, including a scientific name, Human Coronavirus-Erasmus Medical Center (HCoV-EMC), which was then used in scientific literature.[12] In the article, they noted four respiratory human coronaviruses (HCoV) known to be endemic: 229E, OC43, NL63, and HKU1.[12]
In May 2013, the Coronavirus Study Group of the International Committee on Taxonomy of Viruses adopted the official designation, the Middle East Respiratory Syndrome Coronavirus (MERS-CoV).[20] which was adopted by the World Health Organization to “provide uniformity and facilitate communication about the disease”[21]
By May 2013, 10 of the 22 people who died and 22 of 44 cases reported were in Saudi Arabia and over 80% were male.[22]This gender disparity is thought to be because most women in Saudi Arabia wear veils that cover the mouth and nose, decreasing their chances of being exposed to the virus.[23] By 19 June 2013, MERS had infected at least 60 people with cases reported in Jordan, Qatar, Saudi Arabia, the United Arab Emirates (UAE), Tunisia, Germany, the United Kingdom (UK), France and Italy,[24] with a death toll of 38.[23] Saudi officials expressed great concern that millions of Muslims from around the world would potentially be exposed to the virus during the autumn Hajj, or pilgrimage to Mecca.[25]
In May 2014, the WHO said it was monitoring the situation as global cases of MERS appeared to be on the rise, but said the situation did not yet constitute a health emergency. On 3 June 2014, Saudi Arabia revised the country’s total cases of MERS to date to 688 cases after re-examining the data as part of an effort to better understand the disease. A total of 282 people had died from MERS. The numbers represented a jump of 113 cases and 92 deaths. Despite the jump in reported cases, the number of new cases was on the decline according to Tariq Madany, head of the medical advisory council. At the same time, the Saudi deputy health minister was fired, the second high level health official fired within two months.[26]
On 4 June 2014, a study published in the The New England Journal of Medicine indicated that camel to human transmission of the virus was possible. In November 2013, a man became ill with MERS after tending to a sick camel. DNA samples taken from the man, who eventually died of the virus, and the sick animal were virtually identical providing very strong evidence the man had got the virus from the camel.[27]
Reported cases
Tunisia[edit]
On 20 May 2013, the novel coronavirus reached Tunisia killing one man and infecting two of his relatives. Tunisia was the eighth country to be affected by MERS-CoV after Jordan, Saudi Arabia, Qatar, the United Kingdom, France, Germany, and the United Arab Emirates.[28]
According to a European Centre for Disease Prevention and Control (ECDC) publication, on April 2014, Tunisia had a total of 3 cases with 1 fatality.[2]
In April 2012, six hospital workers were diagnosed with acute respiratory failure of unknown origin. Of the six, two died. All the cases were reported to the European Centre for Disease Prevention and Control (ECDC). After the September identification of a novel CoV strain, a retroactive analysis of the hospital workers was performed. Epidemiologists discovered the Jordan cases. Using stored laboratory samples for all six, it was found that samples from the two patients who had died tested positive for nCoV.[29][30]
On 24 April 2014, a 25 year-old male was found positive for the coronavirus. He had history of exposure to camels and had consumed camel milk.[31]
Malaysia[edit]
On 16 April 2014, Malaysia reported its first MERS-COV related death.[32] The person was a 54 year-old man who had traveled to Jeddah, Saudi Arabia, together with pilgrimage group composed of 18 people, from 15–28 March 2014. He became ill by 4 April, and sought remedy at a clinic in Johor on 7 April. He was hospitalized by 9 April and died on 13 April.[33]
Indonesia[edit]
On May 11, 2014, two persons on Medan were suspected infected by MERS-Cov (Middle Eastern Respiratory Syndrome-Corona Virus).[34]
On 31 October 2013, the World Health Organization (WHO) confirmed that one person in Oman has MERS.[35] The WHO said “the patient in Oman is a 68-year-old man from Al Dahkliya region who became ill” on 26 October 2013.[35]
Philippines[edit]
On 16 April 2014, an OFW who returned from Al Ain City, United Arab Emirates was found positive for MERS-CoV at theNinoy Aquino International Airport (NAIA). The said person was tested for the said virus in the United Arab Emirates (UAE) but immediately travelled to Manila. Doctors from UAE later contacted Department of Health (DOH) confirming the condition of the OFW. The said OFW, who was working as a nurse in the UAE, had contact with the Filipino paramedic who had died recently in the said country. The OFW together with four of his family members who fetched him at the airport were quarantined.[36][37] In a press release on 19 April, DOH announced that the OFW who UAE doctors found positive for MERS-CoV was found negative for the virus in an subsequent test by Research Institute for Tropical Medicine (RITM). Explaining further with the test, Secretary Enrique Ona explained, “Since ten days had lapsed from the reported testing date at the UAE, our task force right away got in touch with him and decided to perform a test on him, and fortunately, as well for the comfort of everybody, the findings of our Research Institute for Tropical Medicine, he tested negative.”[38] In the said press release, DOH also announced that they are tracking all other 414 passengers of Etihad Airways Flight 424 (the flight the OFW took from Abu Dhabi, UAE to Manila) in order to be tested.[38][39] As of 24 April, 408 passengers were already contacted, of whom 252 were already tested; out of this numbers, 221 were found to be negative. The remaining 6 passengers have yet to be contacted.[40][41][42]
Saudi Arabia[edit]
The first known case of a previously unknown coronavirus was identified in a 60-year-old Saudi Arabian man with acute pneumonia, who died of renal failure in June 2012.[12][43][44] As of 12 May 2013, two more deaths have been reported in the al-Ahsa region of Saudi Arabia. In the latest cluster of infections, 15 cases had been confirmed, and nine of those patients had died.[45] Ten of the 22 people who died and 22 of 44 cases reported were in Saudi Arabia.[22] An unconfirmed case in another Saudi citizen, for which no clinical information was available, was also reported around this time. On 22 September 2012, the Saudi Ministry of Health (MOH) announced that the two cases involving Saudi citizens, caused by what they termed a “rare pattern of coronavirus,” had both proven fatal.
Two of the Saudi Arabia cases were from the same family and from that family at least one additional person presented similar symptoms but tested negative for the novel coronavirus.[46]
On 21 February 2013, WHO stated that there had been 13 laboratory-confirmed cases, 6 cases (4 fatal) from Saudi Arabia, 2 cases (both fatal) from Jordan, 2 cases from Qatar, and 3 from the UK.[47]
In March 2013, the Saudi Arabia Ministry of Health reported the death of a 39-year-old man, the 15th case and 9th death reported to WHO.[48] On 2 May 2013, the Saudi Ministry of Health announced five people died and two other people were in critical condition with confirmed cases of a SARS-like virus.[49] The delays in obtaining data and absence of basic information (which would usefully include: sex, age, other medical conditions and smoking status) have been noted and decried by Dr. Margaret Chan and in Pro-Med comments on numerous briefings. At the annual meeting of the world’s health ministers, Dr. Chan, director-general of the World Health Organization, said the virus was now her “greatest concern.”[50]
On 28 May 2013, the Saudi Ministry of Health reported five more cases of MERS-CoV. The cases have been “recorded among citizens in the Eastern Region, ranging in age from 73 to 85 years, but they have all chronic diseases.” With this announcement, the unofficial global case count reached 49 while the death toll stands at 24 according to the CDC.[51] As of 26 June 34 deaths have been recorded in the kingdom.[25]
On 1 August 2013, the World Health Organization announced three new MERS-CoV cases in that Saudi Arabia, all of them in women, two of whom were healthcare workers. “With the three new cases, Saudi Arabia’s posted MERS tally increases to 74 cases with 39 deaths. The cases raise the WHO’s MERS count to 94 cases and 46 deaths.”[52]
On 31 October 2013, the WHO announced that three patients in Saudi Arabia died of MERS.[35] The patients were one woman and two men and “all had underlying medical conditions but all reported having had no contact with animals before falling ill”.[35]
Early of 23 April 2014, 11 new cases including a first case for Mecca were reported by the Health Ministry.[53] An additional 13 cases were reported on the same day. With the additional reported cases, there are now a total of 285 cases with 83 deaths in the Kingdom.[54]
Due to fears of the MERS virus, attendance in the hajj in 2013 was lower than the previous year.[55][56] The Saudi government asked “elderly and chronically ill Muslims to avoid the hajj this year” and restricted the number of people allowed “to perform the pilgrimage”.[57][58][59]
Saudi Health Minister Abdullah Al-Rabia said “that authorities had so far detected no cases among the pilgrims” of MERS.[55] However, the Spanish government, in November 2013, reported a woman in Spain, who had recently traveled toSaudi Arabia for the Islamic pilgrimage, contracted the disease.[60]
United Arab Emirates[edit]
On 14 April 2014, one Filipino paramedic died in the United Arab Emirates, with six other reported to be infected with the virus.[32][61] On 17 April, the UAE Ministry of Health reported another fatality and four additional cases, including the Filipino medical worker who travelled to the Philippines on 16 April.[33]
On 21 April 2014, the Health Ministry of UAE reported an additional 9 cases.[62]
The Ministry of Health and Medical Education of Iran reported that two women had been diagnosed with MERS[63] and on 29 May 2014 one of the women died of the disease in the city of Kerman. According to Dr. Mohammad Mehdi Gooya, Chief of the Center for Management of Contagious Diseases of Iran, the patient had been diagnosed with high blood pressure and her immune system, therefore, wasn’t strong enough to fend off the disease.[64] The second patient is said to be in a good condition.[65]
Four days later, on 4 June 2014, the Ministry of Health reported that 3 more people including a doctor and a nurse who came in contact with the deceased patient are suspected to have contracted the disease. The victim’s son-in-law is also reported to have been infected. According to Dr. Gooya, the infection of 1 out of the 3 suspected patients is confirmed and more tests are under way to determine the situation of the other two patients.[66]
South Korea[edit]
In May 2015, the first case in South Korea was confirmed in a man who had visited several Middle Eastern countries.[67] As of 12 June 2015, ten people in South Korea have died from this outbreak, with 122 confirmed cases of infection.[68] There have been at least 3800 quarantined.[69]
On 7 May 2013, a case was confirmed in Nord departement of France in a man who had previously traveled to Dubai, United Arab Emirates.[70]
On 12 May 2013, in a case of human to human transmission, a man previously hospitalized in the same room as the first patient was confirmed by French Ministry of Social Affairs and Health.[71]
France reported its first death from MERS near the end of May 2013.[72] On 28 May 2013, a report by the Associated Presssaid a French patient died of the novel coronavirus related to SARS.[73] Fifty percent of those infected have died.[73]
On 20 April 2014, Greece reported its first MERS-CoV case. The infected individual was a 69-year-old Greek male who had returned to Greece on April 17 from Saudi Arabia. People with close contact with the infected man were identified and are being followed up.[74][75]
On 31 May 2013, the Italian health ministry announced its first case of MERS-CoV in a 45-year-old man who had traveled to Jordan. The patient is being currently treated in a hospital in Tuscany and his condition was reported as not life-threatening.[76][77]
On 1 November 2013, a woman who had recently traveled to Saudi Arabia for the Hajj, contracted the disease. She is stated to be in stable condition, and investigators from the World Health Organization are investigating whom she came in contact with.[60]
United Kingdom[edit]
In February 2013, the first UK case of the novel coronavirus was confirmed in Manchester in an elderly man who had recently visited the Middle East and Pakistan; it was the 10th case globally.[78] The man’s son, whom he visited in the hospital in Birmingham, was immuno-suppressed because of a brain tumour, and contracted the virus, providing the first clear evidence for person-to-person transmission.[79][80] He died on 19 February 2013.[81][82]
The second patient was a 49-year-old Qatari man who had visited Saudi Arabia before falling ill. He was flown privately by air ambulance from Doha to London on 11 September where he was admitted to St Mary’s Hospital and later was transferred to St Thomas’s Hospital.[83] As a result of Dr Zaki’s post on Pro-MED, the novel coronavirus was quickly identified.[84][85] He was treated for respiratory disease and, like the first patient in Saudi Arabia, died of renal failure in October 2012.[84][85][86][87][88]
Another patient who had been in Guys and St Thomas hospital in the UK since September 2012 after visiting the Middle East died on 28 June 2013. A spokesperson for the hospital stated that “Guys and St Thomas can confirm that the patient with severe respiratory illness due to novel coronavirus (MERS-COV) sadly died on Friday 28 June, after his condition deteriorated despite every effort and full supportive treatment.”[89]
As of April 2014, the European Centre for Disease Prevention and Control reported a total of 4 cases in the United Kingdom, 3 of which were fatalities.[2]
North America[edit]
United States[edit]
On 2 May 2014, the United States Centers for Disease Control (CDC) confirmed the first diagnosis of MERS-CoV in the United States in Indiana. The man diagnosed was a healthcare worker who had been in Saudi Arabia a week earlier, and was reported to be in good condition.[90][91] Another case, a Florida man from the Orlando area, has been reported, and a third Illinois man is as yet asymptomatic but has tested positive for a past infection with the healthcare worker from Indiana. The latter case is the first human-to-human transmission in the United States.[92] On 28 May 2014, the CDC announced that the third person who was found positive for the virus was not infected. The announcement came after a further laboratory analysis by CDC indicating that the person was never infected with the virus.[93]
Alex Infohub 
